Mast cells mediate allergies, hypersensitivities, host defense, and venom neutralization. An
area of recent interest is the contribution of mast cells to inflammatory pain. Here we found
that specific, local activation of mast cells produced plantar hyperalgesia in mice. Basic
secretagogue compound 48/80 induced plantar mast cell degranulation accompanied by
thermal hyperalgesia, tissue edema, and neutrophil influx in the hindpaws of ND4 Swiss
mice. Blocking mast cell degranulation, neutrophil extravasation, and histamine signaling …

Objective: The cranial dura mater contains plenty of mast cells and is principally supplied by
the middle meningeal artery which has a key role in the generation of headaches.
Neurogenic inflammation caused by perivascular nerve activation and dural vasodilation is
held responsible for migraine pain. Dural mast cells contribute neurogenic inflammation and
migraine via vasoactive and proinflammatory mediators in their secretory granules. In the
present study, it was aimed to investigate vasoactive effect of mast cell degranulating agent …